Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian
population. Cystic fibrosis-related liver disease (CFLD) is defined as the pathogenesis …

In the last 25 years, a number of animal models, mainly rodents, have been generated with
the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte …

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …

Bile duct epithelial cells, also known as cholangiocytes, regulate the composition of bile and
its flow. Acquired, congenital and genetic dysfunctions in these cells give rise to a set of …

Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver …

Cholangiocytes, the epithelial cells lining the bile ducts, are an important subset of liver
cells. They are involved in the modification of bile volume and composition, and respond to …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a
progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier …

Hepatocellular carcinoma (HCC) is a frequent neoplasia and a leading cause of
inflammation‐related cancer mortality. Despite that most HCCs arise from persistent …