Noncoding RNAs (ncRNAs) are a class of nucleotide sequences that cannot be translated
into peptides. ncRNAs can function post-transcriptionally by splicing complementary …

The stria vascularis (SV) is a stratified epithelium in the lateral wall of the mammalian
cochlea, responsible for both endolymphatic ion homeostasis and generation of the …

Abstract Background and Purpose Cisplatin‐induced sensorineural hearing loss is a
significant clinical challenge. Although the potential effects of brain‐derived neurotrophic …

Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and
connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing …

The treatment of inner ear disorders remains challenging due to the intrinsic anatomical
barriers. The majority treatments and delivery approaches for accessing inner hair cells are …

Clinical translation of gene therapy has been challenging, due to limitations in current
delivery vehicles such as traditional viral vectors. Herein, we report the use of gRNA: Cas9 …

Background A primary obstacle in age-related hearing loss (ARHL) study is the lack of
accelerated senescent models in vitro that explore the precise underlying mechanism in …

Objective To investigate the expression and clinical significance of miR-34c and miR-29b in
peripheral blood of patients with sensorineural hearing loss. Methods 140 patients with …