Role of pore-forming toxins in bacterial infectious diseases
Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …
required for virulence in a large number of important pathogens, including Streptococcus …
Bacterial manipulation of innate immunity to promote infection
L Diacovich, JP Gorvel - Nature Reviews Microbiology, 2010 - nature.com
The mammalian innate immune response provides a barrier against invading pathogens.
Innate immune mechanisms are used by the host to respond to a range of bacterial …
Innate immune mechanisms are used by the host to respond to a range of bacterial …
Integrated MicroRNA-mRNA-Analysis of Human Monocyte Derived Macrophages upon Mycobacterium avium subsp. hominissuis Infection
J Sharbati, A Lewin, B Kutz-Lohroff, E Kamal… - PloS one, 2011 - journals.plos.org
Background Many efforts have been made to understand basal mechanisms of
mycobacterial infections. Macrophages are the first line of host immune defence to …
mycobacterial infections. Macrophages are the first line of host immune defence to …
MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
MYC activates different metabolic programs in a cell-type-and cell-status-dependent
manner. However, the role of MYC in inflammatory macrophages has not yet been …
manner. However, the role of MYC in inflammatory macrophages has not yet been …
Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence
A gene fragment corresponding to the region of difference-1 (RD-1) of the Mycobacterium
tuberculosis genome, spanning open reading frames Rv3871 to Rv3879c, is missing in all …
tuberculosis genome, spanning open reading frames Rv3871 to Rv3879c, is missing in all …
Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development
Mycobacterium tuberculosis (Mtb) infects human alveolar macrophages and relies on the
inhibition of phagosome acidification and maturation. This is, in part, dependent on the …
inhibition of phagosome acidification and maturation. This is, in part, dependent on the …
ESAT-6 inhibits production of IFN-γ by Mycobacterium tuberculosis-responsive human T cells
X Wang, PF Barnes, KM Dobos-Elder… - The Journal of …, 2009 - journals.aai.org
The Mycobacterium tuberculosis early secreted Ag of 6 kDa (ESAT-6) is a potent Ag for
human T cells and is a putative vaccine candidate. However, ESAT-6 also contributes to …
human T cells and is a putative vaccine candidate. However, ESAT-6 also contributes to …
The stringent response and Mycobacterium tuberculosis pathogenesis
J Prusa, DX Zhu, CL Stallings - Pathogens and disease, 2018 - academic.oup.com
During infection, the host restrains Mycobacterium tuberculosis (Mtb) from proliferating by
imposing an arsenal of stresses. Despite this onslaught of attacks, Mtb is able to persist for …
imposing an arsenal of stresses. Despite this onslaught of attacks, Mtb is able to persist for …
The Co-Operonic PE25/PPE41 Protein Complex of Mycobacterium tuberculosis Elicits Increased Humoral and Cell Mediated Immune Response
S Tundup, N Pathak, M Ramanadham… - PloS one, 2008 - journals.plos.org
Background Many of the PE/PPE proteins are either surface localized or secreted outside
and are thought to be a source of antigenic variation in the host. The exact role of these …
and are thought to be a source of antigenic variation in the host. The exact role of these …
Innate immune responses to M. tuberculosis infection
K Natarajan, M Kundu, P Sharma, J Basu - Tuberculosis, 2011 - Elsevier
A prerequisite for successful establishment of Mycobacterium tuberculosis in the host is its
ability to survive after internalization in alveolar macrophages that they encounter after …
ability to survive after internalization in alveolar macrophages that they encounter after …