Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in
vertebrate and invertebrate nervous systems. Prominent family members are the neural cell …

The L1 cell adhesion molecule (L1CAM) plays a major role in the development of the
nervous system and in the malignancy of human tumors. In terms of biological function …

Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian
carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

The increased cap-independent translation of anti-apoptotic proteins is involved in the
development of drug resistance in lung cancer but signalling events regulating this are …

Alzheimer's disease (AD) is a neurodegenerative brain disorder associated with the loss of
synapses between neurons in the brain. Synaptic cell adhesion molecules are cell surface …

The neuronal cell adhesion and recognition molecule L1 does not only 'keep cells
together'by way of homophilic and heterophilic interactions, but can also promote cell …

Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of
Alzheimer's disease (AD). Previously, we reported a correlation between cell adhesion …

L1 cell adhesion molecule (L1CAM) is aberrantly expressed in several tumor types where it
is causally linked to malignancy and therapy resistance, acting also as a poor prognosis …