DNA topoisomerases as a drug target in Leishmaniasis: Structural and mechanistic insights

P Kour, P Saha, DK Sharma, K Singh - International Journal of Biological …, 2024 - Elsevier
Leishmaniasis, caused by a protozoan parasite, is among humanity's costliest banes, owing
to the high mortality and morbidity ratio in poverty-stricken areas. To date, no vaccine is …

Genomic Insight of Leishmania Parasite: In-Depth Review of Drug Resistance Mechanisms and Genetic Mutations

K Bharadava, TK Upadhyay, RS Kaushal, I Ahmad… - ACS …, 2024 - ACS Publications
Leishmaniasis, which is caused by a parasitic protozoan of the genus Leishmania, is still a
major threat to global health, impacting millions of individuals worldwide in endemic areas …

Design, synthesis, and biological evaluation of 3, 3′-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity

P Kour, P Saha, S Bhattacharya, D Kumari… - RSC Medicinal …, 2023 - pubs.rsc.org
Leishmaniasis, one of the neglected diseases, ranks second to malaria in the cause of
parasitic mortality and morbidity. The present chemotherapeutic regimen faces the …

Anti-Leishmania compounds can be screened using Leishmania spp. expressing red fluorescence (tdTomato)

MGFML Cruz, AMM Santi… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
The main challenges associated with leishmaniasis chemotherapy are drug toxicity, the
possible emergence of resistant parasites, and a limited choice of therapeutic agents …

Repurposing FDA approved drugs against Sterol C-24 methyltransferase of Leishmania donovani: a dual in silico and in vitro approach

D Kumari, V Jamwal, A Singh, SK Singh, S Mujwar… - Acta Tropica, 2024 - Elsevier
Leishmaniasis is a disease caused by the parasite Leishmania donovani affecting
populations belonging to developing countries. The present study explores drug …

Design, synthesis, and biological evaluation of eugenol-isoxazoline hybrid derivatives as potential anti-leishmanial agents

D Rani, D Kumari, A Bhushan, V Jamwal… - Journal of Molecular …, 2024 - Elsevier
Leishmaniasis is a group of protozoan parasitic diseases caused by various Leishmania
species. The clinical manifestations range from skin abrasions to lethal infection in the …

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

F Mohamed Abdoul-Latif, A Ainane, IH Aboubaker… - Processes, 2023 - mdpi.com
In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green
synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria …

Detergent-free parasite transformation and replication assay for drug screening against intracellular Leishmania amastigotes

S Sifontes-Rodríguez, AR Escalona-Montaño… - Journal of …, 2023 - Elsevier
Leishmaniasis is an infectious disease caused by protozoan species in the genera
Leishmania and Endotrypanum. Current antileishmanial drugs are limited due to adverse …

Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14-α demethylase of Leishmania donovani: A comprehensive in vitro and …

D Kumari, P Kour, CP Singh, R Choudhary… - International Journal of …, 2024 - Elsevier
Parthenium hysterophorus plant has a diverse chemical profile and immense bioactive
potential. It exhibits excellent pharmacological properties such as anti-cancer, anti …

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

D Dourado, TS Medeiros… - Beilstein Journal of …, 2024 - beilstein-journals.org
Leishmaniasis is a neglected tropical disease that has affected more than 350 million
people worldwide and can manifest itself in three different forms: cutaneous …