Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory
response, which is essential for the proper functioning of our immune system. When …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied
in diverse inflammatory disease models. Membrane perforation and cell swelling induced by …

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2
(TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which …

Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

Inflammasome activation plays a crucial role in the progression to more severe stages of
non-alcoholic fatty liver disease (NAFLD), representing a promising therapeutic target …

Autoimmune diseases arise when the immune system mistakenly attacks the body's own
tissues, leading to chronic inflammation and organ damage. These disorders are complex …

In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

Autoimmunity refers to an organism's immune response against its own healthy cells,
tissues, or components, potentially leading to irreversible damage to vital organs. Central …