A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across
diverse areas of biology and medicine. The recognition of mitochondria as a major …

The mitochondrial genomes of most eukaryotes lack a variable number of tRNA genes. This
lack is compensated for by import of a small fraction of the corresponding cytosolic tRNAs …

Mitochondrial diseases are one of the largest groups of neurological genetic disorders.
Despite continuous efforts of the scientific community, no cure has been developed, and …

Base editors are a type of double-stranded break (DSB)-free gene editing technology that
has opened up new possibilities for precise manipulation of mitochondrial DNA (mtDNA) …

In plants, as in most eukaryotic cells, import of nuclear-encoded cytosolic tRNAs is an
essential process for mitochondrial biogenesis. Despite its broad occurrence, the …

All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can
be traced down to a single endosymbiotic event between two probably prokaryotic …

In many eukaryotes, tRNA import from the cytosol into mitochondria is essential for
mitochondrial biogenesis and, consequently, for cell viability. Recent work has begun to …

Trypanosoma brucei has three distinct∼ 20S editosomes that catalyze RNA editing by the
insertion and deletion of uridylates. Editosomes with the KREN1 or KREN2 RNase III type …

Nanomedicine promises to play an important role in next generation therapy, including
Nucleic acid/Gene therapy. To accomplish this, innovative nanotechnologies will be needed …