The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the maturation of a
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …

Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Many potential treatments for Alzheimer's disease target amyloid-β peptides (Aβ), which are
widely presumed to cause the disease. The microtubule-associated protein tau is also …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor in the defence
against oxidative stress. Here we provide evidence that activation of the Nrf2 pathway …

Protein accumulation is a hallmark of many neurodegenerative disorders. In Alzheimer's
disease (AD), a hyperphosphorylated form of the protein tau (p-tau) forms intracellular …

Neuronal inclusions comprised of the microtubule-associated protein tau are found in
numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's …

Aggregation of tau protein in the brain is associated with a class of neurodegenerative
diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by …

The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a
neuropathological hallmark of tauopathies, including Alzheimer's disease (AD) and chronic …

This week marks a century since the first description of Alzheimer's disease (AD). Despite
approval of several drugs for AD, the disease continues to rob millions of their memories and …