Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a
single genetic mutation that leads to repeated polymerization and depolymerization of …

Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell
disease (SCD), affecting 6–10% of adult SCD patients. Various mechanisms and theories …

Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the
process of phase II metabolism of many substrates, including xenobiotics, anticancer and …

Sickle cell disease (SCD), a hereditary form of chronic hemolytic anemia, is characterized by
acute vascular occlusion and chronic complications as pulmonary hypertension (PH), a …

Abstract Recently, Glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1
(GSTT1), and their interaction with hypertension risk have been focused on. However, the …

Background: Glutathione S-transferases (GSTs) genes single-nucleotide polymorphisms
(SNPs) have been connected with the susceptibility of nonalcoholic fatty liver disease …

Background CYP and GST gene families detoxify tobacco carcinogens and have been
linked to the risk of non-small cell lung carcinoma (NSCLC). Aim Independent and combined …

Background: Glutathione system plays an important role in the protection of cells and tissue
against damage from oxidative stress. Impairment of the glutathione system due to genetic …

Platelets play important roles in vascular health. Activation of platelet may contribute to
coagulation and inflammation. Evidence suggests circulating platelets are chronically …