Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae
MS Youse, NS Abutaleb, A Nocentini… - Journal of Medicinal …, 2024 - ACS Publications
Drug-resistant gonorrhea is caused by the bacterial pathogen Neisseria gonorrhoeae, for
which there is no recommended oral treatment. We have demonstrated that the FDA …
which there is no recommended oral treatment. We have demonstrated that the FDA …
Insights into Novel Arylazopyrazolo[1,5-a]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and …
O Al kamaly, AS Younes, MH Ibrahim, MF Harras… - ACS …, 2025 - ACS Publications
MurA is a pivotal target in antimicrobial therapy owing to its fundamental function in bacterial
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
In vitro and in vivo evaluation of novel ursolic acid derivatives as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)
Y Sun, X Li, Y Wang, X Shang, W Huang, S Ang, D Li… - Bioorganic …, 2025 - Elsevier
The misuse and abuse of antibiotics have led to the increase of drug resistance and the
emergence of multi-drug resistant bacteria. Therefore, it is an urgent need to develop novel …
emergence of multi-drug resistant bacteria. Therefore, it is an urgent need to develop novel …
Efficient synthesis of N-phenyl-4-(trifluoromethyl) thiazol-2-amine and its antibacterial activity
X Tian, J Zhang, Y Li - Synlett, 2025 - thieme-connect.com
N-phenyl-4-(trifluoromethyl) thiazole-2-amine is an important class of fluorinated
heterocyclic compounds, particularly in the fields of fungicides and insecticides. However …
heterocyclic compounds, particularly in the fields of fungicides and insecticides. However …