The skin is a multi-layered organ, often displaying associated structures, that establishes a
protective interface between the organism and the surrounding environment. In mammals …

Cetacean skin continues to be the investigative focus of researchers from several different
scientific disciplines. Yet, most research on the basic functions of lipo‐keratinocytes, which …

The loss of previously adaptive traits is typically linked to relaxation in selection, yet the
molecular steps leading to such repeated losses are rarely known. Molecular studies of loss …

Major protein components of the mammalian skin barrier are encoded by genes clustered in
the Epidermal Differentiation Complex (EDC). The skin of cetaceans, ie whales, porpoises …

Genomes are dynamic biological units, with processes of gene duplication and loss
triggering evolutionary novelty. The mammalian skin provides a remarkable case study on …

Peptidylarginine deiminases (PADs) are a family of phylogenetically conserved calcium-
dependent enzymes which cause post-translational protein deimination. This can result in …

Melatonin, the hormone of darkness, is a peculiar molecule found in most living organisms.
Emerging as a potent broad-spectrum antioxidant, melatonin was repurposed into extra …

The rapid expansion of high-quality genome assemblies, exemplified by ongoing initiatives
such as the Genome-10K and i5k, demands novel automated methods to approach …

With the advent of next‐generation sequencing, an increasing number of cases of de novo
variants in domestic animals have been reported in scientific literature primarily associated …

The appearance of mammalian-specific skin features was a key evolutionary event
contributing for the elaboration of physiological processes such as thermoregulation …