Towards novel potential molecular targets for antidepressant and antipsychotic pharmacotherapies
YM Kositsyn, MS de Abreu, TO Kolesnikova… - International Journal of …, 2023 - mdpi.com
Depression and schizophrenia are two highly prevalent and severely debilitating
neuropsychiatric disorders. Both conventional antidepressant and antipsychotic …
neuropsychiatric disorders. Both conventional antidepressant and antipsychotic …
Dysphania ambrosioides (L.) Mosyakin and Clemants: bridging traditional knowledge, photochemistry, preclinical investigations, and toxicological validation for …
F Kandsi, FZ Lafdil, N El Hachlafi, M Jeddi… - Naunyn-Schmiedeberg's …, 2024 - Springer
Dysphania ambrosioides L.(Chenopodiaceae) is a Moroccan medicinal plant known locally
as “M'Khinza.” It is widely used in traditional medicine to treat numerous ailments, such as …
as “M'Khinza.” It is widely used in traditional medicine to treat numerous ailments, such as …
Unveiling the phytochemical profile, in vitro bioactivities evaluation, in silico molecular docking and ADMET study of essential oil from Clinopodium nepeta grown in …
Clinopodium nepeta is an aromatic species appertaining to the Lamiaceae family, and has
been mentioned for its numerous traditional uses and pharmacological properties …
been mentioned for its numerous traditional uses and pharmacological properties …
An in-silico investigation based on molecular simulations of novel and potential brain-penetrant GluN2B NMDA receptor antagonists as anti-stroke therapeutic agents
GluN2B-induced activation of NMDA receptors plays a key function in central nervous
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …
QSAR, ADME-Tox, molecular docking and molecular dynamics simulations of novel selective glycine transporter type 1 inhibitors with memory enhancing properties
A structural class of forty glycine transporter type 1 (GlyT1) inhibitors, was examined using
molecular modeling techniques. The quantitative structure-activity relationships (QSAR) …
molecular modeling techniques. The quantitative structure-activity relationships (QSAR) …
3D-QSAR, ADME-Tox in silico prediction and molecular docking studies for modeling the analgesic activity against neuropathic pain of novel NR2B-selective NMDA …
A new class of selective antagonists of the N-Methyl-d-Aspartate (NMDA) receptor subunit
2B have been developed using molecular modeling techniques. The three-dimensional …
2B have been developed using molecular modeling techniques. The three-dimensional …
Design of novel anti-cancer drugs targeting TRKs inhibitors based 3D QSAR, molecular docking and molecular dynamics simulation
Tropomyosin receptor kinase (TRK) enzymes are responsible for different types of tumors
caused by neurotrophic tyrosine receptor kinase gene fusion and have been identified as an …
caused by neurotrophic tyrosine receptor kinase gene fusion and have been identified as an …
QSAR, molecular docking, and molecular dynamics simulation–based design of novel anti-cancer drugs targeting thioredoxin reductase enzyme
Thioredoxin reductase (TrxR) plays an important role in the reduction of thioredoxin (Trx),
which is found to be involved in the upregulation of a diversity of tumors, including those …
which is found to be involved in the upregulation of a diversity of tumors, including those …
[HTML][HTML] In-silico investigations of novel tacrine derivatives potency against Alzheimer's disease
Tacrine was originally used as a palliative treatment for Alzheimer's disease (AD). But early
applications soon revealed a number of its side effects on human health. That's why we …
applications soon revealed a number of its side effects on human health. That's why we …
[HTML][HTML] QSAR modeling, molecular docking and molecular dynamic simulation of phosphorus-substituted quinoline derivatives as topoisomerase I inhibitors
M Lahyaoui, H El-Idrissi, T Saffaj, B Ihssane… - Arabian Journal of …, 2023 - Elsevier
As they facilitate the cleavage of single and double stranded DNA to relax supercoils,
unwind catenanes, and condense chromosomes in eukaryotic cells, Topoisomerase plays …
unwind catenanes, and condense chromosomes in eukaryotic cells, Topoisomerase plays …