Quaternary carbons are ubiquitous in bioactive molecules; however, synthetic methods for
the construction of this motif remain underdeveloped. Here, we report the synthesis of …

Methyl groups are well understood to play a critical role in pharmaceutical molecules,
especially those bearing saturated heterocyclic cores. Accordingly, methods that install …

An unprecedented straightforward reductive amidation of chloroalkanes with nitroarenes
was readily accomplished by merging iron catalysis with visible-light photoredox catalysis. A …

As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial
role in personalized medicine, including early diagnosis, patient screening, and treatment …

Under mild blue-light irradiation, α-acylated saturated heterocycles undergo a
photomediated one-atom ring contraction that extrudes a heteroatom from the cyclic core …

Basic amines show broad bioactivity and remain a promising source of new medicines. The
direct photoalkylation of imines offers a promising strategy for complex amines. However …

This article reports the outcome of an in silico analysis of more than 12,000 small molecule
drugs and drug impurities, identifying the nitrosatable structures, assessing their potential to …

Organic solvent nanofiltration (OSN) is a low-energy alternative for continuous separations
in the chemical industry. As the pharmaceutical sector increasingly turns toward continuous …

Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts
among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly …

Sodium triflinate (CF3SO2Na) is an inexpensive bench-stable radical CF3 source that is
often activated by external oxidants such as peroxides. However, despite the commercial …