FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

Precision oncology implies the ability to predict which patients will likely respond to specific
cancer therapies based on increasingly accurate, high‐resolution molecular diagnostics as …

Background Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …

Sarcomas are a heterogeneous group of rare malignancies originating from mesenchymal
tissues with limited therapeutic options. Recently, alterations in components of the fibroblast …

Soft-tissue sarcomas (STS) are rare malignancies that account for 1% of adult cancers and
comprise more than 50 entities. Current therapeutic options for advanced-stage STS are …

Tissue-agnostic drug development is a major step forward in offering treatment options for
rare tumors. Sarcomas are heterogeneous rare malignancies with more than 100 subtypes …

Ovarian cancer (OC) is one of the leading causes of female deaths. However, the molecular
pathogenesis of OC has still remained elusive. This study aimed to explore the potential …

Members of the Protein Tyrosine Phosphatase (PTPs) family are associated with growth
regulation and cancer development. Acting as natural counterpart of tyrosine kinases (TKs) …

Purpose Rapidly evolving genomics technologies, in particular comprehensive next-
generation sequencing (NGS), have led to exponential growth in the understanding of …