Reverse engineering and identification in systems biology: strategies, perspectives and challenges

AF Villaverde, JR Banga - Journal of the Royal Society …, 2014 - royalsocietypublishing.org
The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …

Mathematical modelling of chemical processes—obtaining the best model predictions and parameter estimates using identifiability and estimability procedures

KAP McLean, KB McAuley - The Canadian Journal of Chemical …, 2012 - Wiley Online Library
Chemical engineers who develop fundamental models often have difficulties estimating all
model parameters due to problems with parameter identifiability and estimability. These two …

[图书][B] Uncertainty quantification: theory, implementation, and applications

RC Smith - 2024 - SIAM
Uncertainty quantification serves a central role for simulation-based analysis of physical,
engineering, and biological applications using mechanistic models. From a broad …

On identifiability of nonlinear ODE models and applications in viral dynamics

H Miao, X Xia, AS Perelson, H Wu - SIAM review, 2011 - SIAM
Ordinary differential equations (ODEs) are a powerful tool for modeling dynamic processes
with wide applications in a variety of scientific fields. Over the last two decades, ODEs have …

Addressing parameter identifiability by model-based experimentation

A Raue, C Kreutz, T Maiwald, U Klingmüller, J Timmer - IET systems biology, 2011 - IET
Mathematical description of biological processes such as gene regulatory networks or
signalling pathways by dynamic models utilising ordinary differential equations faces …

Development of RC model for thermal dynamic analysis of buildings through model structure simplification

Z Wang, Y Chen, Y Li - Energy and Buildings, 2019 - Elsevier
Data-driven models based on thermal resistor-capacitor networks (RC models) are useful in
enhancing the energy performance of buildings. This paper presents a simple yet effective …

A novel group contribution method for the prediction of the derived cetane number of oxygenated hydrocarbons

M Dahmen, W Marquardt - Energy & Fuels, 2015 - ACS Publications
The assessment of the ignition quality of a wide range of oxygenated hydrocarbons is one
key challenge in the identification of novel molecular entities qualifying as biofuels or biofuel …

Good modeling practice for industrial chromatography: mechanistic modeling of ion exchange chromatography of a bispecific antibody

F Rischawy, D Saleh, T Hahn, S Oelmeier… - Computers & Chemical …, 2019 - Elsevier
In the biopharmaceutical industry, development and characterization of chromatography
processes is typically based on statistical models. Although these approaches are easy to …

[HTML][HTML] Sieve estimation of constant and time-varying coefficients in nonlinear ordinary differential equation models by considering both numerical error and …

H Xue, H Miao, H Wu - Annals of statistics, 2010 - ncbi.nlm.nih.gov
This article considers estimation of constant and time-varying coefficients in nonlinear
ordinary differential equation (ODE) models where analytic closed-form solutions are not …

Linking models and experiments

D Bonvin, C Georgakis, CC Pantelides… - Industrial & …, 2016 - ACS Publications
This position paper gives an overview of the discussion that took place at FIPSE 2 at
Aldemar Resort, east of Heraklion, Crete, in June 21–23, 2014. This is the second …