[HTML][HTML] Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy
F Moradbeygi, Y Ghasemi, AR Farmani… - Biomedicine & …, 2023 - Elsevier
Patients receiving high-dose methotrexate (HDMTX) for malignancies are exposed to
diverse complications, including nephrotoxicity, hepatotoxicity, mucositis, myelotoxicity …
diverse complications, including nephrotoxicity, hepatotoxicity, mucositis, myelotoxicity …
The relevance of telomerase and telomere-associated proteins in B-acute lymphoblastic Leukemia
THA da Mota, R Camargo, ER Biojone… - Genes, 2023 - mdpi.com
Telomeres and telomerase are closely linked to uncontrolled cellular proliferation,
immortalization and carcinogenesis. Telomerase has been largely studied in the context of …
immortalization and carcinogenesis. Telomerase has been largely studied in the context of …
Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate
C Lin, R Ma, X Zeng, B Zhang, T Cao, S Jiao… - Frontiers in …, 2024 - frontiersin.org
Background High-dose methotrexate (HD-MTX) is commonly employed in the treatment of
malignant tumors in children and young adults due to its distinctive therapeutic efficacy …
malignant tumors in children and young adults due to its distinctive therapeutic efficacy …
Clinical Risk Factors for High‐Dose Methotrexate‐Induced Oral Mucositis Following Individualized Dosing
Background Oral mucositis affects about 20% of children undergoing high‐dose
methotrexate (HDMTX) for acute lymphoblastic leukemia (ALL), despite existing …
methotrexate (HDMTX) for acute lymphoblastic leukemia (ALL), despite existing …
Effects of SCT genetic polymorphisms on methotrexate concentrations and toxicities in Chinese children with acute lymphoblastic leukemia
M Li, DQ Zhao, XY Kong, SM Wang - Leukemia & Lymphoma, 2025 - Taylor & Francis
Solute carrier (SLC) transporters play a crucial role in facilitating the cellular uptake of
various anticancer drugs, such as methotrexate (MTX). This study aimed to analyze the …
various anticancer drugs, such as methotrexate (MTX). This study aimed to analyze the …
The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia …
M Naderisorki, H Karami, E Salehifar… - Middle East Journal of …, 2024 - mejc.sums.ac.ir
Background: Acute lymphoblastic leukemia (ALL) represents the predominant childhood
cancer. High-dose methotrexate is integral to leukemia treatment protocols. This study …
cancer. High-dose methotrexate is integral to leukemia treatment protocols. This study …
Impact of Body Mass Index on Outcome, Toxicity and Pharmacokinetics in Patients with Acute Lymphoblastic Leukemia
CE Gustafsson - 2023 - search.proquest.com
Background: Overweight and obesity are growing health problems. Obesity has been
associated with both a higher risk of contracting cancer and increased cancer-related …
associated with both a higher risk of contracting cancer and increased cancer-related …
Impact of body mass index on outcome, toxicity and pharmacokinetics in patients with acute lymphoblastic leukemia
C Egnell Gustafsson - 2023 - openarchive.ki.se
Background: Overweight and obesity are growing health problems. Obesity has been
associated with both a higher risk of contracting cancer and increased cancer-related …
associated with both a higher risk of contracting cancer and increased cancer-related …