The global challenges presented by drug-resistant bacterial infections have stimulated much
activity in finding new treatments. This review summarizes the progress and setbacks of non …

Iron is an essential element for virtually all cell types due to its role in energy metabolism,
nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and …

Nowadays, increasing extended-spectrum β-lactamase (ESBL)-producing bacteria have
become a global concern because of inducing resistance toward most of the antimicrobial …

Isoprenoids are vital for all organisms, in which they maintain membrane stability and
support core functions such as respiration. IspH, an enzyme in the methyl erythritol …

The Escherichia coli that produces extended-spectrum lactamases (ESBL-E. coli) can
develop resistance to many antibiotics. The control of ESBL-E. coli disorders is challenging …

The limited therapeutic options and the recent emergence of multidrug-resistant Candida
species present a significant challenge to human medicine and underscore the need for …

Antibiotic resistance critically limits treatment options for infection caused by opportunistic
pathogens such as enterococci. Here, we investigate the antibiotic and immunological …

Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections
that can often evolve to severe infections. The rise of antibiotic-resistant strains has driven …

Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty
to effectively treat due to their protection inside the host cell and the development of …

Clostridioides difficile bacteria can cause life-threatening diarrhea and colitis owing to
limited treatment options and unacceptably high recurrence rates among infected patients …