Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained
elusive. A new category of pathogenic components, normally dormant within human …

Transposable Elements (TE) are mobile DNA elements that can replicate and insert
themselves into different locations within the host genome. Their propensity to self …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

For millions of years, retroviral infections have challenged vertebrates, occasionally leading
to germline integration and inheritance as ERVs, genetic parasites whose remnants today …

Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …

The immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of …

The human genome contains many endogenous retroviral sequences, and these have been
suggested to play important roles in a number of physiological and pathological processes …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …