Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Mesenchymal stem cell‐based immunomodulation: properties and clinical application

M Wang, Q Yuan, L Xie - Stem cells international, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self‐renewal,
production of clonal cell populations, and multilineage differentiation. They exist in nearly all …

Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: a phase IIb, randomized, placebo …

WS Lee, HJ Kim, KI Kim, GB Kim… - Stem cells translational …, 2019 - academic.oup.com
Mesenchymal stem cells (MSCs) have been the focus of an emerging treatment for
osteoarthritis. However, few studies reported about outcomes of an intra-articular injection of …

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

HM Knochelmann, CJ Dwyer, SR Bailey… - Cellular & molecular …, 2018 - nature.com
The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent
factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial

A Vega, MA Martín-Ferrero, F Del Canto… - …, 2015 - journals.lww.com
Background Osteoarthritis is the most prevalent joint disease and a common cause of joint
pain, functional loss, and disability. Conventional treatments demonstrate only modest …

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications

ME Castro-Manrreza… - Journal of immunology …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into
mesenchymal lineages and that can be isolated from various tissues and easily cultivated in …

The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy

J Zhang, X Huang, H Wang, X Liu, T Zhang… - Stem cell research & …, 2015 - Springer
Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory
diseases because of their immunosuppressive and tissue repair properties. Moreover, their …