The biology of thymic stromal lymphopoietin (TSLP)
SF Ziegler, F Roan, BD Bell, TA Stoklasek… - Advances in …, 2013 - Elsevier
Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
Therapies for allergic inflammation: refining strategies to induce tolerance
CA Akdis - Nature medicine, 2012 - nature.com
Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …
symptoms but do not change the chronic course of disease. There is no established method …
Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease
Y Li, W Wang, Z Lv, Y Li, Y Chen, K Huang… - The Journal of …, 2018 - journals.aai.org
The epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been
implicated in asthma pathogenesis because they promote Th2-type cytokine synthesis, but …
implicated in asthma pathogenesis because they promote Th2-type cytokine synthesis, but …
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
MAM Willart, K Deswarte, P Pouliot, H Braun… - Journal of Experimental …, 2012 - rupress.org
House dust mite (HDM) is one of the most common allergens worldwide. In this study, we
have addressed the involvement of IL-1 in the interaction between HDM and the innate …
have addressed the involvement of IL-1 in the interaction between HDM and the innate …
Th9 cell development requires a BATF-regulated transcriptional network
T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic
inflammation in mice, and are associated with allergic disease in humans. It has not been …
inflammation in mice, and are associated with allergic disease in humans. It has not been …
The importance of TSLP in allergic disease and its role as a potential therapeutic target
A Cianferoni, J Spergel - Expert review of clinical immunology, 2014 - Taylor & Francis
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine similar to IL-7, whose
gene is located on chromosome 5q22. 1 and it exerts its biological function through the …
gene is located on chromosome 5q22. 1 and it exerts its biological function through the …
Thymic stromal lymphopoietin and allergic disease
SF Ziegler - Journal of Allergy and Clinical Immunology, 2012 - Elsevier
The importance of the epithelium in initiating and controlling immune responses is becoming
more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the …
more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the …
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine important for the
initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this …
initiation and development of T helper (Th2) cell-mediated allergic inflammation. In this …
Secretory immunoglobulin a immunity in chronic obstructive respiratory diseases
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …
respiratory diseases that share features such as the obstruction of small airways and …
Mechanisms of peripheral tolerance to allergens
OU Soyer, M Akdis, J Ring, H Behrendt, R Crameri… - Allergy, 2013 - Wiley Online Library
The immune system is regulated to protect the host from exaggerated stimulatory signals
establishing a state of tolerance in healthy individuals. The disequilibrium in immune …
establishing a state of tolerance in healthy individuals. The disequilibrium in immune …