Sex steroid hormones are synthesized from cholesterol and exert pleiotropic effects notably
in the central nervous system. Pioneering studies from Baulieu and colleagues have …

Over the past two decades, the classical understanding of steroid action has been updated
to include rapid, membrane-initiated, neurotransmitter-like functions. While steroids were …

Estradiol (E 2) can act in the brain in a relatively fast manner (ie, seconds to minutes) usually
through signaling initiated at the cell membrane. Brain-derived E 2 has thus been …

In addition to the transcriptional activity of their liganded nuclear receptors, estrogens, such
as estradiol (E2), modulate cell functions, and consequently physiology and behavior, within …

The ovaries are often thought of as the main and only source of estrogens involved in the
regulation of female behavior. However, aromatase, the key enzyme for estrogen synthesis …

It is becoming clear that steroid hormones act not only by binding to nuclear receptors that
associate with specific response elements in the nucleus but also by binding to receptors on …

In the present study, we have investigated the effects of 30-day dietary (pre-pubertal)
exposure to different doses (0 (control), 1, 10, 50, 200 and 400 mg/kg bodyweight/day) of di …

Decades of work have established the brain as a source of steroid hormones, termed
'neurosteroids'. The neurosteroid neuroestradiol is produced in discrete brain areas and …

Mounting experimental evidence demonstrate that sex neuroactive steroids (neurosteroids)
are essential for memory formation. Neurosteroids have a profound impact on the function …

Aggressive behavior plays an essential role in survival and reproduction across animal
species—it has been observed in insects, fish, reptiles, and mammals including humans …