The Importance of “Negative” Results: Lipid Lessons in Coronavirus Biology

SR Leist, JR Mock - American Journal of Respiratory Cell and …, 2023 - atsjournals.org
Cholesterol is an essential constituent of animal cell membranes, and cholesterol levels and
components of the cholesterol biosynthetic pathway are tightly regulated (1). The complex …

[HTML][HTML] The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

PJ Baker, AC Bohrer, E Castro, EP Amaral… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from
asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine …

胆固醇-25-羟化酶对乙脑病毒复制的影响及机制研究.

邓东青, 龙启舟, 聂映, 吴家红 - China Tropical Medicine, 2024 - search.ebscohost.com
目的探究胆固醇-25-羟化酶(cholesterol 25-hydroxylase, CH25H) 对流行性乙型脑炎病毒(
Japanese enceph⁃ alitis virus, JEV) 复制的影响及其作用机制, 为抗JEV 药物的研发提供靶标 …

肝受体同源物-1 通过转录激活多药耐药基因1 调控肝癌细胞对奥沙利铂的敏感性

刘金连, 潘楠楠, 陈雪, 肖利佳 - China Tropical Medicine, 2024 - search.ebscohost.com
统计学意义(P< 0.05); 同时其细胞增殖能力显著增强, MDR1 mRNA 表达水平明显升高.
在HepG2 细胞中敲低LRH-1 表达后, 细胞在奥沙利铂处理下, IC50 显著降低, 为1.012 μmol/L …

[引用][C] Characterisation of a pathogen-exploited and host-defense G protein-coupled receptor during viral infections

CX Foo - 2024 - espace.library.uq.edu.au
Oxysterols are emerging as bioactive molecules with diverse immunomodulatory functions.
Over the past decade, studies have elucidated the role of these oxysterols in the immune …