Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that often presents
clinically at an advanced stage and that may be confused with chronic pancreatitis (CP) …

A severe lack of early diagnosis coupled with resistance to most available therapeutic
options renders pancreatic cancer as a major clinical concern. The limited efficacy of current …

It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …

Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …

MicroRNAs are short noncoding RNAs consisting of 18–25 nucleotides that target specific
mRNA moieties for translational repression or degradation, thereby modulating numerous …

The great majority of cancer deaths are due to metastasis, which remains a poorly
understood pathological process. The formation of a metastasis reflects a succession of …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need.
While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much …

Pancreatic cancer is a fatal cancer which is expected to exceed breast cancer as the third
foremost source of cancer mortality by 2025. This cancer has been associated with several …