Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future

P Greco, G Nencini, I Piva, M Scioscia, CA Volta… - Acta Neurologica …, 2020 - Springer
Hypoxic–ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage
that is caused by a lack of oxygen to the brain during neonatal period. The incidence is …

Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis of …

BB Abate, M Bimerew, B Gebremichael… - PloS one, 2021 - journals.plos.org
Background Hypoxic perinatal brain injury is caused by lack of oxygen to baby's brain and
can lead to death or permanent brain damage. However, the effectiveness of therapeutic …

Advances in therapies to treat neonatal hypoxic-ischemic encephalopathy

AK Ranjan, A Gulati - Journal of clinical medicine, 2023 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …

Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies

I Serrenho, M Rosado, A Dinis, C M. Cardoso… - International Journal of …, 2021 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and
morbidity in the perinatal period. This condition results from a period of ischemia and …

Hypoxic‐ischemic‐related cerebrovascular changes and potential therapeutic strategies in the neonatal brain

C Disdier, BS Stonestreet - Journal of neuroscience research, 2020 - Wiley Online Library
Abstract Perinatal hypoxic‐ischemic (HI)‐related brain injury is an important cause of
morbidity and long‐standing disability in newborns. The only currently approved therapeutic …

Therapies for neonatal encephalopathy: Targeting the latent, secondary and tertiary phases of evolving brain injury

AA Chakkarapani, H Aly, M Benders, CM Cotten… - Seminars in Fetal and …, 2021 - Elsevier
In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

[HTML][HTML] Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal …

Y Li, JJ Zhang, RJ Chen, L Chen, S Chen… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Oxidative stress and neuroinflammation play crucial roles in the progression of
neonatal hypoxic-ischemic brain damage (HIBD). Genistein, a natural phytoestrogen, has …

Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway

T Chen, Y Hu, L Lu, Q Zhao, X Tao, B Ding… - Frontiers in …, 2023 - frontiersin.org
Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death
and neurological sequelae, but currently there is no effective therapy drug for HIE. Both …

[HTML][HTML] A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy

JM Korf, LD McCullough, V Caretti - Translational Pediatrics, 2023 - ncbi.nlm.nih.gov
Methods We included full articles and book chapters published in English on PubMed with
references to “hypoxic ischemic encephalopathy”,“birth asphyxia”,“therapeutic hypothermia” …

Biomarkers of hypoxic–ischemic encephalopathy: a systematic review

I Caramelo, M Coelho, M Rosado… - World Journal of …, 2023 - Springer
Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early
hours lack objective measurement tools. Therefore, this systematic review aims to identify …