Cells respond to environmental cues by mobilizing signal transduction cascades that
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …

Microtubules, tirelessly animated and highly dynamic structures, are vital for most cellular
processes and their intricacies are still being revealed even after a century since their …

Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian
carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug …

We performed a deep proteogenomic analysis of bulk tumor and laser microdissection
enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue …

Background. The 5‐year overall survival rate of ovarian cancer (OC) patients is less than
40%. Hypoxia promotes the proliferation of OC cells and leads to the decline of cell …

Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by
laser microdissection from thin sections across spatially separated levels of ten high-grade …

Acquired resistance to oxaliplatin is considered as the primary reason for failure in colorectal
cancer (CRC) therapy. Identifying the underlying resistance mechanisms may improve CRC …

The primary or acquired resistance to anti-VEGF inhibitors remains a common problem in
cancer treatment. Therefore, identifying potential biomarkers enables a better understanding …

Neuroendocrine cells have been implicated in therapeutic resistance and worse overall
survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for …

Ovarian cancer often develops resistance to conventional therapies, hampering their
effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after …