Testicular torsion in vivo models: Mechanisms and treatments

A Minas, S Mahmoudabadi, NS Gamchi… - …, 2023 - Wiley Online Library
Background Testicular torsion is a condition in which a testis rotates around its longitudinal
axis and twists the spermatic cord. This in turn results in a significant decrease in blood flow …

Germ cell apoptosis and survival in testicular inflammation

MS Theas - Andrologia, 2018 - Wiley Online Library
Male infertility is due to genetics, hormonal or environmental causes, or is idiopathic.
Azoospermia is linked to local testicular microenvironment deregulation, with inflammatory …

Beneficial effects of dapsone on ischemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes in rat

P Dejban, N Rahimi, N Takzare, M Jahansouz… - Theriogenology, 2019 - Elsevier
Testicular torsion is a serious urologic emergency and one of the causes of infertility in
males. Hence, prompt diagnosis and treatment are important to prevent testicular damages …

Gum Acacia attenuates cisplatin toxic effect spermatogenesis dysfunction and infertility in rats

AE Nofal, YA Okdah, MI Rady, HZ Hassaan - International journal of …, 2023 - Elsevier
This study aimed to investigate the potential benefits Gum Arabic/Acacia senegal (GA) in
mitigating the harmful effects of cisplatin (CP) on spermatogenesis and testicular health in …

Effect of metformin on germ cell‐specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats

M Ghasemnejad‐Berenji, M Ghazi‐Khansari… - Andrologia, 2018 - Wiley Online Library
The study was designed to evaluate the effects of metformin on apoptosis and epididymal
sperm quality in a rat testicular ischaemia/reperfusion (I/R) injury model. A total of 72 male …

The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice

SS Saeedi Saravi, A Hasanvand… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Acetaminophen overdose is regarded to a common cause of acute liver failure. The
hepatotoxicity leads to mitochondrial oxidative stress and subsequent necrotic …

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

RE Akhigbe, AF Odetayo, TM Akhigbe, MA Hamed… - Heliyon, 2024 - cell.com
Testicular torsion is a urological emergency that involves the twisting of the spermatic cord
along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive …

[HTML][HTML] Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion …

M Ghasemnejad-Berenji, M Ghazi-Khansari… - Biomedicine & …, 2018 - Elsevier
The aim of this study was to investigate the effects of rapamycin (rapa) and metformin (met),
combined administration on testicular torsion-detorsion (T/D) injury. A total of 108 male rats …

Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following …

I Yazdani, R Majdani, M Ghasemnejad-Berenji… - BMC Pharmacology and …, 2022 - Springer
Background Testicular torsion is a pathological condition which needs emergency surgical
intervention. However, after surgical reperfusion, oxidative stress factors cause to germ cell …

Protective effects of sumatriptan on ischaemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes of rat

P Dejban, N Rahimi, N Takzare, M Jahansouz… - Andrologia, 2019 - Wiley Online Library
This study was planned to evaluate the effects of sumatriptan, 5‐HT1B/1D receptors agonist,
on ischaemia/reperfusion injury in bilateral testes after unilateral testicular torsion/detorsion …