Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
Breaking the convention: sialoglycan variants, coreceptors, and alternative receptors for influenza A virus entry
U Karakus, MO Pohl, S Stertz - Journal of virology, 2020 - Am Soc Microbiol
The influenza A virus (IAV) envelope protein hemagglutinin binds α2, 6-or α2, 3-linked sialic
acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this …
acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this …
The mammary glands of cows abundantly display receptors for circulating avian H5 viruses
M Ríos Carrasco, A Gröne, JMA van den Brand… - Journal of …, 2024 - journals.asm.org
Influenza A viruses (IAVs) from the H5N1 2.3. 4.4 b clade are circulating in dairy farms in the
USA.; ruminants were presumed not to be hosts for IAVs. Previously, IAV-positive …
USA.; ruminants were presumed not to be hosts for IAVs. Previously, IAV-positive …
Three amino acid changes in avian coronavirus spike protein allow binding to kidney tissue
KM Bouwman, LM Parsons, AJ Berends… - Journal of …, 2020 - Am Soc Microbiol
Infectious bronchitis virus (IBV) infects ciliated epithelial cells in the chicken respiratory tract.
While some IBV strains replicate locally, others can disseminate to various organs, including …
While some IBV strains replicate locally, others can disseminate to various organs, including …
Influenza D virus utilizes both 9-O-acetylated N-acetylneuraminic and 9-O-acetylated N-glycolylneuraminic acids as functional entry receptors
Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to
other hosts. We have previously demonstrated that IDV binds both 9-O-acetylated N …
other hosts. We have previously demonstrated that IDV binds both 9-O-acetylated N …
Host range of influenza A virus H1 to H16 in Eurasian ducks based on tissue and receptor binding studies
JH Verhagen, P Eriksson, L Leijten, O Blixt… - Journal of …, 2021 - Am Soc Microbiol
Dabbling and diving ducks partly occupy shared habitats but have been reported to play
different roles in wildlife infectious disease dynamics. Influenza A virus (IAV) epidemiology in …
different roles in wildlife infectious disease dynamics. Influenza A virus (IAV) epidemiology in …
[HTML][HTML] The avian influenza A virus receptor SA-α2, 3-Gal is expressed in the porcine nasal mucosa sustaining the pig as a mixing vessel for new influenza viruses
Influenza A viruses (IAVs) originate from wild birds but have on several occasions jumped
host barriers and are now also circulating in humans and mammals. The IAV host receptors …
host barriers and are now also circulating in humans and mammals. The IAV host receptors …
Modified sialic acids on mucus and erythrocytes inhibit influenza A virus hemagglutinin and neuraminidase functions
KN Barnard, BK Alford-Lawrence, DW Buchholz… - Journal of …, 2020 - Am Soc Microbiol
Sialic acids (Sia) are the primary receptors for influenza viruses and are widely displayed on
cell surfaces and in secreted mucus. Sia may be present in variant forms that include O …
cell surfaces and in secreted mucus. Sia may be present in variant forms that include O …
N-Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses
CM Spruit, X Zhu, I Tomris, M Ríos-Carrasco… - Journal of …, 2022 - Am Soc Microbiol
Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on
the cell surface. Hosts of IAV variably express two major forms of sialic acid, N …
the cell surface. Hosts of IAV variably express two major forms of sialic acid, N …
Analysis of the evolution of pandemic influenza A (H1N1) virus neuraminidase reveals entanglement of different phenotypic characteristics
M Dai, W Du, C Martínez-Romero, T Leenders… - MBio, 2021 - Am Soc Microbiol
The influenza A virus (IAV) neuraminidase (NA) is essential for virion release from cells and
decoy receptors and an important target of antiviral drugs and antibodies. Adaptation to a …
decoy receptors and an important target of antiviral drugs and antibodies. Adaptation to a …