Background Exposure to excess levels of the essential trace element manganese produces
cognitive, psychiatric, and motor abnormalities. The understanding of Mn neurotoxicology is …

The Alzheimer's amyloid precursor protein (APP) belongs to a conserved gene family that
also includes the mammalian APLP1 and APLP2, the Drosophila APPL, and the C. elegans …

The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …

Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin
organization and function. Among the genes coding for the MYST family of KATs (KAT5 …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of
DNA methylation that is highly expressed in many cancers. Here, we use transgenic …

The finite proliferative potential of normal human cells leads to replicative cellular
senescence, which is a critical barrier to tumour progression in vivo,,. We show that the …

A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of
ketones. While KDs improve certain health conditions and are popular for weight loss …

Background Gastric cancer continues to be one of the deadliest cancers in the world and
therefore identification of new drugs targeting this type of cancer is thus of significant …

Hepatocellular carcinomas (HCCs) are characterized by frequent somatic genomic copy
number alterations (CNAs), with most of them biologically unexplored. Here, we performed …

Background: PIM1 kinase is coexpressed with c-MYC in human prostate cancers (PCs) and
dramatically enhances c-MYC-induced tumorigenicity. Here we examine the effects of a …