The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …

Conspectus Catalytic asymmetric cycloadditions and cascade cyclizations are a major focus
for the enantioselective construction of chiral carbo-and heterocycles. A number of chiral …

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …

Cycloaddition reactions are of great interest due to their potential and rapid construction of
optically enriched spiro-cyclic products. 3-Methyleneindolinones have been proven to be a …

Spirocyclic compounds are abundant in biologically active products. However, the divergent
synthesis of spirocyclic compounds using low-cost and abundant available starting materials …

An unprecedented asymmetric catalytic (4+ 2) annulation reaction of aryl-substituted γ-
methylidene-δ-valerolactones (GMDVs) with isatin-derived para-quinone methides (p-QMs) …

The first catalytic asymmetric multiple vinylogous addition reactions initiated by Meinwald
rearrangement of vinyl epoxides were realized by employing chiral N, N′‐dioxide/ScIII …