Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

The Ras superfamily is a fascinating example of functional diversification in the context of a
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …

Several studies have linked cilia and Hedgehog signaling, but the precise roles of ciliary
proteins in signal transduction remain enigmatic. Here we describe a mouse mutation …

The tripartite DENN module, comprised of a N-terminal longin domain, followed by DENN,
and d-DENN domains, is a GDP-GTP exchange factor (GEFs) for Rab GTPases, which are …

Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental
evolutionary transitions in the history of life on earth. This event, which is estimated to have …

The Ras superfamily is comprised of at least four large families of regulatory guanosine
triphosphate–binding proteins, including the Arfs. The Arf family includes three different …

The ADP-ribosylation factors (Arfs) are six proteins within the larger Arf family and Ras
superfamily that regulate membrane traffic. Arfs all share numerous biochemical activities …

The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …

Cilia are microtubule‐based, cell‐surface projections whose machinery is evolutionarily
conserved. In vertebrates, cilia are observed on almost every cell type and are either motile …