From purines to purinergic signalling: molecular functions and human diseases

Z Huang, N Xie, P Illes, F Di Virgilio, H Ulrich… - … and Targeted Therapy, 2021 - nature.com
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Hyperuricemia and its related diseases: mechanisms and advances in therapy

L Du, Y Zong, H Li, Q Wang, L Xie, B Yang… - … and Targeted Therapy, 2024 - nature.com
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and …

GC Drosos, D Vedder, E Houben, L Boekel… - Annals of the …, 2022 - ard.bmj.com
Objective To develop recommendations for cardiovascular risk (CVR) management in gout,
vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD) …

2020 American College of Rheumatology guideline for the management of gout

JD FitzGerald, N Dalbeth, T Mikuls… - Arthritis & …, 2020 - Wiley Online Library
Objective To provide guidance for the management of gout, including indications for and
optimal use of urate‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other …

Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the National Health and Nutrition Examination Survey, 2007–2016

M Chen‐Xu, C Yokose, SK Rai… - Arthritis & …, 2019 - Wiley Online Library
Objective To estimate the current prevalence rates and decadal trends of gout and
hyperuricemia in the US, as well as the prevalence of urate‐lowering therapy (ULT) among …

2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases

JM Gwinnutt, M Wieczorek, A Balanescu… - Annals of the …, 2023 - ard.bmj.com
Objectives A European League Against Rheumatism taskforce was convened to review the
literature and develop recommendations on lifestyle behaviours for rheumatic and …

Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease

C Borghi, E Agabiti-Rosei, RJ Johnson… - European journal of …, 2020 - Elsevier
During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

[HTML][HTML] Documento de información y consenso para la detección y manejo de la enfermedad renal crónica

R García-Maset, J Bover, JS de la Morena… - nefrologia, 2022 - Elsevier
La enfermedad renal crónica (ERC) es un importante problema de salud pública a nivel
mundial afectando a más del 10% de la población española. Se asocia a elevada …

[HTML][HTML] Gout epidemiology and comorbidities

JA Singh, A Gaffo - Seminars in arthritis and rheumatism, 2020 - Elsevier
Objective To review the epidemiology of gout and associated comorbidities. Methods We
review the key published studies of the epidemiology of gout and associated comorbidities …

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout

P Richette, M Doherty, E Pascual, V Barskova… - Annals of the …, 2020 - ard.bmj.com
Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed.
New data on imaging and clinical diagnosis have become available since the first EULAR …