Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

The non-essential amino acids serine and glycine are used in multiple anabolic processes
that support cancer cell growth and proliferation (reviewed in ref.). While some cancer cells …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1)
stimulates anabolic processes underlying cell growth. We found that mTORC1 increases …

Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during
glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and …