Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to
alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here …

Hypothalamic-pituitary adrenal (HPA) axis dysregulation has long been implicated in stress-
related disorders such as major depression and post-traumatic stress disorder …

The development of regenerative medicine provides new options for the treatment of end-
stage liver diseases. Stem cells, such as bone marrow mesenchymal stem cells, embryonic …

Stress-elevated glucocorticoids cause circadian disturbances and gut-brain axis (GBA)
disorders, including irritable bowel syndrome (IBS). We hypothesized that the glucocorticoid …

The primary role of adipose tissue stem cells (ADSCs) is to support the function and
homeostasis of adipose tissue in physiological and pathophysiological conditions. However …

Objective As the only E2 conjugating enzyme for the SUMO system, Ubc9-mediated
SUMOylation has been recognized to regulate diverse biological processes, but its impact …

In human languages, a palindrome reads the same forward as backward (eg,'madam'). In
regulatory DNA, a palindrome is an inverted sequence repeat that allows a transcription …