An overview of novel agents for cervical cancer treatment by inducing apoptosis: Emerging drugs ongoing clinical trials and preclinical studies
L Liu, M Wang, X Li, S Yin, B Wang - Frontiers in medicine, 2021 - frontiersin.org
As the leading cause of cancer death, cervical cancer ranks fourth for both incidence and
mortality. Cervical cancer incidence and mortality rates have reportedly decreased over the …
mortality. Cervical cancer incidence and mortality rates have reportedly decreased over the …
JAK/STAT signaling and cervical cancer: from the cell surface to the nucleus
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway constitutes a rapid signaling module from the cell surface to the nucleus, and …
pathway constitutes a rapid signaling module from the cell surface to the nucleus, and …
Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer …
S She, Y Zhao, B Kang, C Chen, X Chen, X Zhang… - Cell Death & …, 2020 - nature.com
Despite substantial advances in treating cervical cancer (CC) with surgery, radiation and
chemotherapy, patients with advanced CC still have poor prognosis and significantly …
chemotherapy, patients with advanced CC still have poor prognosis and significantly …
The relevant participation of prolactin in the genesis and progression of gynecological cancers
A Ramírez-de-Arellano, JC Villegas-Pineda… - Frontiers in …, 2021 - frontiersin.org
Prolactin (PRL) is a hormone produced by the pituitary gland and multiple non-pituitary sites,
vital in several physiological processes such as lactation, pregnancy, cell growth, and …
vital in several physiological processes such as lactation, pregnancy, cell growth, and …
Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild …
RH Tian, Y Bai, JY Li, KM Guo - Brain research, 2019 - Elsevier
Patients suffering from depression most commonly present with symptoms associated with
the autonomic nervous system. Despite the satisfactory results achieved following treatment …
the autonomic nervous system. Despite the satisfactory results achieved following treatment …
[HTML][HTML] Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway
S Shan, J Niu, R Yin, J Shi, L Zhang, C Wu, H Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
Molecular targeted therapy has become an emerging promising strategy in cancer
treatment, and screening the agents targeting at cancer cell specific targets is very desirable …
treatment, and screening the agents targeting at cancer cell specific targets is very desirable …
Suppressing the metastatic properties of the breast cancer cells using STAT3 decoy oligodeoxynucleotides: a promising approach for eradication of cancer cells by …
Due to the presence of cancer stem cells (CSCs), breast cancer often relapsed after
conventional therapies. Strategies that induce differentiation of CSCs will be helpful in …
conventional therapies. Strategies that induce differentiation of CSCs will be helpful in …
The role of IL-22 in cancer
ZE Hunzeker, L Zhao, AM Kim, JM Parker, Z Zhu… - Medical Oncology, 2024 - Springer
Interleukin-22, discovered in the year of 2000, is a pleiotropic Th17 cytokine from the IL-10
family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and …
family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and …
In-silico and in-vitro investigation of STAT3-PIM1 heterodimeric complex: Its mechanism and inhibition by curcumin for cancer therapeutics
The functional activity among STAT3 and PIM1, are key signaling events for cancer cell
function. Curcumin, a diarylheptanoid isolated from turmeric, effectively inhibits STAT3 …
function. Curcumin, a diarylheptanoid isolated from turmeric, effectively inhibits STAT3 …
STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells
H Nakamura, A Taguchi… - International …, 2016 - spandidos-publications.com
In cervical cancer, p53-induced apoptosis is abrogated by human papilloma virus (HPV)-
derived oncoprotein E6. Although tumor necrosis factor-related apoptosis-inducing ligand …
derived oncoprotein E6. Although tumor necrosis factor-related apoptosis-inducing ligand …