The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Cancer cachexia is a complex multifactorial syndrome marked by a continuous depletion of
skeletal muscle mass associated, in some cases, with a reduction in fat mass. It is …

How regular physical activity is able to improve health remains poorly understood. The
release of factors from skeletal muscle following exercise has been proposed as a possible …

Movement and regular physical activity are two important factors that help the human body
prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart …

Exercise is a powerful and effective preventive measure against chronic diseases by
increasing energy expenditure and substrate mobilization. Long-duration acute exercise …

Exercise and physical activity levels influence myokine release from skeletal muscle and
contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL)-6 …

The impact of intrauterine growth restriction (IUGR) on health in humans is well-recognized.
It is the second leading cause of perinatal mortality worldwide, and it is associated with …

Insulin resistance onset in skeletal muscle is characterized by the impairment of insulin
signaling, which reduces the internalization of glucose, known as glucose uptake, into the …

In previous studies, adipocytes were found to play an important role in regulating whole-
body nutrition and energy balance, and are also important in energy metabolism, hormone …

The two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4,
both substrates for AMPK, play important roles in exercise metabolism and contraction …