Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families.
Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T …

Troponin is the regulatory complex of the myofibrillar thin filament that plays a critical role in
regulating excitation-contraction coupling in the heart. Troponin is composed of three distinct …

BACKGROUND Levels of MBCK can be increased in patients with skeletal muscle injury or
renal failure in the absence of myocardial injury, causing diagnostic confusion. This study …

Abstract Cardiac troponin (Tn) I (CTnI), compared with skeletal TnI, contains extra amino
acids (32 to 33) at its amino terminus, including two adjacent serine residues. These two …

Myocardial stunning is characterized by decreased myofilament Ca sup 2+ responsiveness.
To investigate the molecular basis of stunned myocardium, we performed PAGE and …

Recent reports have demonstrated the presence of two isoforms of troponin I in the human
fetal heart, namely, cardiac troponin I and slow skeletal muscle troponin I. Structural and …

Cardiac troponin T (cTnT), a protein essential for calcium-regulated myofibrillar ATPase
activity, is expressed in the human heart as four isoforms (cTnT1 through cTnT4, numbered …

Troponin I is the inhibitory component of troponin, the thin filament regulatory complex in
striated muscle. Separate genes encode cardiac-specific fast and slow skeletal-specific …

Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric
molecular switch, directly regulating the contractile event in concert with intracellular calcium …

Background—Genetic studies of cardiomyopathy and heart failure have limited throughput
in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model …