Reactivity of oximes for diverse methodologies and synthetic applications

KA Rykaczewski, ER Wearing, DE Blackmun… - Nature …, 2022 - nature.com
Oximes are valuable synthetic building blocks with reactivity modes that enable their use in
diverse methodologies, from cycloadditions to bioconjugation. Their reactivity towards …

DABCO‐Promoted Selective Photochemical C− N Coupling: Access to Unsymmetrical Azahelicenes

RY Balakhonov, IS Mekeda… - Advanced Synthesis & …, 2023 - Wiley Online Library
A multifaceted study on the effect of various factors on the efficiency of photocyclization of
naphthofuran O‐acyl oximes was performed. It showed that without any additives or in the …

Microwave-and thermally promoted iminyl radical cyclizations: A versatile method for the synthesis of functionalized pyrrolines

J Singh, TJ Nelson, SA Mansfield… - The Journal of …, 2022 - ACS Publications
A detailed study of iminyl radical cyclizations of O-aryloximes tethered to alkenes is reported.
The reactions can be triggered by either microwave irradiation or conventional heating in an …

Access to pyrrolines and fused diaziridines by selective radical addition to homoallylic diazirines

Z Ma, X Wu, H Li, Z Cao, C Zhu - Chemical Science, 2024 - pubs.rsc.org
Pyrroline derivatives are common in bioactive natural products and therapeutic agents. We
report here a synthesis of pyrrolines and fused diaziridines by divergent radical cyclization of …

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

C Prakash, R Singh - ChemistrySelect, 2024 - Wiley Online Library
The fluorinated 5‐membered N‐containing heterocyclic compounds have wide utility in
varied fields. The importance of these compounds has encouraged researchers to explore …

Synthesis of the Indolizidine Core of Virosinine A via a Microwave-Promoted Cascade Cyclization Involving Iminyl Radicals

A Ramos, ED Griffin, KH Ho, J Singh, SA Jones… - Organic …, 2024 - ACS Publications
The indolizidine core of virosinine A was synthesized by means of a microwave-promoted
cascade reaction featuring 5-exo-trig iminyl radical cyclization, thiyl radical elimination, and …

Synthesis of multisubstituted carbazol-4-amines from tetrahydrocarbazol-4-one oximes

J Wang, D Gao, AO Oyejobi, N Ji, XY Tang… - Organic Chemistry …, 2024 - pubs.rsc.org
Described herein is a sequential thiolation reaction between tetrahydrocarbazol-4-one
oximes and aryl thiols, affording a wide range of 1, 3-dithiolated carbazol-4-amines, which …

Formal γ-C(sp3)–H Activation of Ketones via Microwave-Promoted and Iminyl-Radical-Mediated 1,5-Hydrogen Atom Transfer

J Singh, SA Jones, TJ Nelson, JA Botello… - The Journal of Organic …, 2023 - ACS Publications
Microwave irradiation of O-phenyloximes triggers N–O homolysis and 1, 5-hydrogen atom
transfer (HAT), resulting in formal γ-C–H functionalization of ketones after trapping of the …

Synthesis, Characterization, and Optimization of Novel Furan-ring Fused Chalcones via Radical Cyclization of α, β-Unsaturated Ketones and Cyclic Ketone

EV Burgaz, B Noshadi, M Yakut - Letters in Organic Chemistry, 2024 - ingentaconnect.com
Novel Furan-ring Fused Chalcones (FFC) were synthesized using a radical cyclization
reaction of α, β-unsaturated ketones with cyclic ketone as the model reaction to attain this …

NIS-Mediated Oxidation of Hydrazones: A Rapid Access to Fused Lactones and Tosylhydrazides

A Takallou, S Al-Shidhani, M Al-Siyabi, A Mobaraki… - Synlett, 2023 - thieme-connect.com
A tandem one-pot strategy for the synthesis of 4-iodo-3-aryl (alkyl)-1H-pyrano [4, 3-b]
quinolin-1-ones and (E)-3-(iodo (phenyl) methylene) isobenzofuran-1-(3H)-ones from 2 …