Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals
associated with atherosclerosis, although the pathophysiological importance and the …

ABSTRACT Stearoyl CoA desaturase 1 (SCD1) catalyzes the rate-limiting step in the
production of MUFA that are major components of tissue lipids. Alteration in SCD1 …

Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …

Chronic inflammation is a key feature of insulin resistance and obesity. Toll‐Like Receptor 4
(TLR4), involved in modulating innate immunity, is an important mediator of insulin …

Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Fatty acid regulation of hepatic lipid metabolism : Current Opinion in Clinical Nutrition &
Metabolic Care Fatty acid regulation of hepatic lipid metabolism : Current Opinion in Clinical …

Stearoyl‐CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown
to play an intrinsic role in the development of obesity and related conditions, such as insulin …