Signaling through the JAK/STAT pathway, recent advances and future challenges
T Kisseleva, S Bhattacharya, J Braunstein… - Gene, 2002 - Elsevier
Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …
Janus kinases: components of multiple signaling pathways
Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …
transduction pathways that govern cellular survival, proliferation, differentiation and …
Hematopoietic cytokine receptor signaling
Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are
mediated by cytokines and their receptors. Proper culmination of these diverse pathways …
mediated by cytokines and their receptors. Proper culmination of these diverse pathways …
Activating alleles of JAK3 in acute megakaryoblastic leukemia
DK Walters, T Mercher, TL Gu, T O'Hare, JW Tyner… - Cancer cell, 2006 - cell.com
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute
myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we developed a …
myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we developed a …
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
Hematopoiesis is the cumulative result of intricately regulated signal transduction cascades
that are mediated by cytokines and their cognate receptors. Proper culmination of these …
that are mediated by cytokines and their cognate receptors. Proper culmination of these …
The Janus kinase family of protein tyrosine kinases and their role in signaling
TC Yeh, S Pellegrini - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
In the early 1990s, the search for protein kinases led to the discovery of a novel family of non-
receptor tyrosine kinases, the Janus kinases or JAKs. These proteins were unusual because …
receptor tyrosine kinases, the Janus kinases or JAKs. These proteins were unusual because …
Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
TJ Pircher, H Petersen, JA Gustafsson… - Molecular …, 1999 - academic.oup.com
Serine phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3
modulates their DNA-binding capacity and/or transcriptional activity. Earlier we suggested …
modulates their DNA-binding capacity and/or transcriptional activity. Earlier we suggested …
Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma
S Umehara, H Higashi, N Ohnishi, M Asaka… - Oncogene, 2003 - nature.com
Helicobacter pylori (H. pylori) is a causative agent of gastrointestinal diseases such as
atrophic gastritis and gastroduodenal ulcer. Infection of cagA-positive H. pylori is also …
atrophic gastritis and gastroduodenal ulcer. Infection of cagA-positive H. pylori is also …
The role of STATs in proliferation, differentiation, and apoptosis
ALF Mui - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
The spectrum of biological systems which makes use of the signal transducers and
activators of transcription (STAT) paradigm extends beyond the interferon system in which it …
activators of transcription (STAT) paradigm extends beyond the interferon system in which it …