Promoting nerve regeneration: electrical stimulation, gene therapy, and beyond

AL O'Brien, JM West, TM Saffari, M Nguyen… - …, 2022 - journals.physiology.org
Peripheral nerve injuries often result in life-altering functional deficits even with optimal
management. Unlike the central nervous system, peripheral nerves have the ability to …

Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries

GD Bittner, JS Bushman, CL Ghergherehchi… - Journal of …, 2022 - Springer
We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve
segment are the most common type of traumatic injury to nervous systems. Segmental-loss …

Polyethylene glycol (PEG) and other bioactive solutions with neurorrhaphy for rapid and dramatic repair of peripheral nerve lesions by PEG-fusion

CL Ghergherehchi, M Mikesh, DR Sengelaub… - Journal of neuroscience …, 2019 - Elsevier
Background Nervous system injuries in mammals often involve transection or segmental
loss of peripheral nerves. Such injuries result in functional (behavioral) deficits poorly …

Myelin clearance is critical for regeneration after peripheral nerve injury

YM Yuan, Y Wang, SH Wu, MY Zhao - Frontiers in Neurology, 2022 - frontiersin.org
Traumatic peripheral nerve injury occurs frequently and is a major clinical and public health
problem that can lead to functional impairment and permanent disability. Despite the …

Polyethylene glycol solutions rapidly restore and maintain axonal continuity, neuromuscular structures, and behaviors lost after sciatic nerve transections in female …

M Mikesh, CL Ghergherehchi… - Journal of …, 2018 - Wiley Online Library
Complete severance of major peripheral mixed sensory–motor nerve proximally in a
mammalian limb produces immediate loss of action potential conduction and voluntary …

Polyethylene glycol: the future of posttraumatic nerve repair? Systemic review

AM Paskal, W Paskal, P Pietruski… - International journal of …, 2019 - mdpi.com
Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair
of nerve lesion does not always guarantee satisfactory motor and sensory function recovery …

Rapid and effective fusion repair of severed digital nerves using neurorrhaphy and bioengineered solutions including polyethylene glycol: A case report

S Lopez, GD Bittner, RC Treviño - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Peripheral nerve injuries (PNIs) that consist of simple nerve severance often result in severe
motor impairment and permanent loss of function. Such patients face significant costs and …

Functional and immunological peculiarities of peripheral nerve allografts

KCS Roballo, JP Gigley, TA Smith… - Neural Regeneration …, 2022 - journals.lww.com
This review addresses the accumulating evidence that live (not decellularized) allogeneic
peripheral nerves are functionally and immunologically peculiar in comparison with many …

Initial findings in traumatic peripheral nerve injury and repair with diffusion tensor imaging

MD Pridmore, GE Glassman, AC Pollins… - Annals of Clinical …, 2021 - Wiley Online Library
Objective Management of peripheral nerve injuries requires physicians to rely on qualitative
measures from patient history, electromyography, and physical exam. Determining a …

Polyethylene glycol treated allografts not tissue matched nor immunosuppressed rapidly repair sciatic nerve gaps, maintain neuromuscular functions, and restore …

M Mikesh, CL Ghergherehchi, S Rahesh… - Journal of …, 2018 - Wiley Online Library
Many publications report that ablations of segments of peripheral nerves produce the
following unfortunate results:(1) Immediate loss of sensory signaling and motor control;(2) …