Structural and chemical biology of terpenoid cyclases

DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

H Jiang, X Wang - Biotechnology Advances, 2023 - Elsevier
Terpenoids are a large class of plant-derived compounds, that constitute the main
components of essential oils and are widely used as natural flavors and fragrances. The …

[HTML][HTML] Releasing the potential power of terpene synthases by a robust precursor supply platform

G Bian, Y Han, A Hou, Y Yuan, X Liu, Z Deng… - Metabolic Engineering, 2017 - Elsevier
Terpenoids represent the largest family of natural products. Their structural diversity is
largely due to variable skeletons generated by terpene synthases. However, terpene …

Exploring novel bacterial terpene synthases

GK Reddy, NGH Leferink, M Umemura, ST Ahmed… - PloS one, 2020 - journals.plos.org
Terpenes are the largest class of natural products with extensive structural diversity and are
widely used as pharmaceuticals, herbicides, flavourings, fragrances, and biofuels. While …

An analysis of characterized plant sesquiterpene synthases

J Durairaj, A Di Girolamo, HJ Bouwmeester… - Phytochemistry, 2019 - Elsevier
Plants exhibit a vast array of sesquiterpenes, C15 hydrocarbons which often function as
herbivore-repellents or pollinator-attractants. These in turn are produced by a diverse range …

Computational prediction of complex cationic rearrangement outcomes

T Klucznik, LD Syntrivanis, S Baś, B Mikulak-Klucznik… - Nature, 2024 - nature.com
Recent years have seen revived interest in computer-assisted organic synthesis,. The use of
reaction-and neural-network algorithms that can plan multistep synthetic pathways have …

Discovering monoterpene catalysis inside nanocapsules with multiscale modeling and experiments

E Pahima, Q Zhang, K Tiefenbacher… - Journal of the American …, 2019 - ACS Publications
Large-scale production of natural products, such as terpenes, presents a significant scientific
and technological challenge. One promising approach to tackle this problem is chemical …

Exploring chemical and biological space of terpenoids

T Zeng, Z Liu, H Liu, W He, X Tang… - Journal of Chemical …, 2019 - ACS Publications
Terpenoids represent the largest family of natural products (NPs) with dramatically chemical
and structural diversity, which makes terpenoids the important compound resources of drug …

Highly selective acid-catalyzed olefin isomerization of limonene to terpinolene by kinetic suppression of overreactions in a confined space of porous metal …

W He, S Tashiro, M Shionoya - Chemical Science, 2022 - pubs.rsc.org
Natural enzymes control the intrinsic reactivity of chemical reactions in the natural
environment, giving only the necessary products. In recent years, challenging research on …