Stress and defense responses in plant secondary metabolites production

T Isah - Biological research, 2019 - SciELO Chile
In the growth condition (s) of plants, numerous secondary metabolites (SMs) are produced
by them to serve variety of cellular functions essential for physiological processes, and …

Camptothecin, over four decades of surprising findings

A Lorence, CL Nessler - Phytochemistry, 2004 - Elsevier
Camptothecin (CPT) is a modified monoterpene indole alkaloid produced by Camptotheca
acuminata (Nyssaceae), Nothapodytes foetida, Pyrenacantha klaineana, Merrilliodendron …

Sustainable bioproduction of phytochemicals by plant in vitro cultures: anticancer agents

M Wink, AW Alfermann, R Franke… - Plant Genetic …, 2005 - cambridge.org
Due to their complex structure with several chiral centres important anticancer agents are
still extracted from plants and not synthesized chemically on a commercial scale …

Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots

A Lorence, F Medina-Bolivar, CL Nessler - Plant Cell Reports, 2004 - Springer
Camptothecin (CPT) is an anticancer and antiviral alkaloid produced by the Chinese tree
Camptotheca acuminata (Nyssaceae) and some other species belonging to the families …

Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

K Saito, H Sudo, M Yamazaki, M Koseki-Nakamura… - Plant Cell Reports, 2001 - Springer
Camptothecin derivatives are used clinically as anti-tumor alkaloids. Camptothecin and its
related compounds are at present obtained by extraction from intact plants, but transformed …

Biotechnology of camptothecin production in Nothapodytes nimmoniana, Ophiorrhiza sp. and Camptotheca acuminata

MK Swamy, S Nath, S Paul, NK Jha… - Applied Microbiology …, 2021 - Springer
Cancer is probably the deadliest human disease in recent years. In the past few years, rapid
clinical progress has been made in the field of anticancer drug development. Plant …

[PDF][PDF] Callus culture for the production of therapeutic compounds

ED Benjamin, GA Ishaku, FA Peingurta… - American Journal of …, 2019 - researchgate.net
Plant-derived compounds retain a special place in the treatment of various diseases across
the world. Their application cuts across every class of disease, where they are found to be …

Camptothecin: therapeutic potential and biotechnology

S Sirikantaramas, T Asano, H Sudo… - Current …, 2007 - ingentaconnect.com
Camptothecin (CPT) and its derivatives have been received considerable attention recently.
Two semi-synthetic derivatives, topotecan and irinotecan, are currently prescribed as …

Culture medium optimization for camptothecin production in cell suspension cultures of Nothapodytes nimmoniana (J. Grah.) Mabberley

VS Karwasara, VK Dixit - Plant biotechnology reports, 2013 - Springer
The effect of culture medium nutrients on growth and alkaloid production by plant cell
cultures of Nothapodytes nimmoniana (J. Grah.) Mabberley (Icacinaceae) was studied with a …

Patterns of accumulation of camptothecin, an anti-cancer alkaloid in Nothapodytes nimmoniana Graham., in the Western Ghats, India: implications for identifying high …

BV Padmanabha, M Chandrashekar, BT Ramesha… - Current Science, 2006 - JSTOR
Camptothecin, a monoterpene indole alkaloid, is regarded as one of the most promising
anticancer drugs of the twenty-first century. Among the various plant sources, the highest …