The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal
and currently untreatable disease characterized by rapid cognitive decline and paralysis …

In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …

Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …

Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

Recent interest in astrocyte activation states has raised the fundamental question of how
these cells, normally essential for synapse and neuronal maintenance, become pathogenic …