Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic,
bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was …

With increased longevity of patients suffering from cystic fibrosis, and widespread lung
transplantation facilities, the sequelae of defective CFTR in other organs than the airways …

Background: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly,
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …

Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …

Metabolic alkalosis, the most common acid–base disorder, is related to significantly
increased mortality in hospitalized patients. Hunting for pH sensors lying in the neutral to …

Cystic fibrosis (CF) is the most common life-threatening genetic disease in the United States
and among people of European descent. Despite the widespread distribution of the cystic …

Background & aims Acid-base disturbances are common in short bowel (SB) patients due to
increased intestinal bicarbonate loss. However, the resulting systemic acid load has not …

Pseudo-Bartter syndrome (PBS) is characterised by hypokalaemic, hyponatraemic and
hypochloraemic metabolic alkalosis in the absence of renal tubules pathology; it is a well …

Aim Renal excretion of excess HCO3− depends on renal cystic fibrosis transmembrane
conductance regulator (CFTR) and is impaired in people with cystic fibrosis (pwCF). Urine …

Background: Non-type-A intercalated cells (IC) in the collecting duct system express the
luminal Cl-/HCO 3-exchanger pendrin and apical and/or basolateral H+-ATPases containing …