Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact

GS Shetye, SG Franzblau, S Cho - Translational Research, 2020 - Elsevier
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA

S Köster, S Upadhyay, P Chandra… - Proceedings of the …, 2017 - National Acad Sciences
Mycobacterium tuberculosis' success as a pathogen comes from its ability to evade
degradation by macrophages. Normally macrophages clear microorganisms that activate …

Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

YM Jacobo-Delgado, A Rodríguez-Carlos… - Frontiers in …, 2023 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is one of the most important infectious agents worldwide
and causes more than 1.5 million deaths annually. To make matters worse, the drug …

The mycobacterial cell envelope: a relict from the past or the result of recent evolution?

AT Vincent, S Nyongesa, I Morneau, MB Reed… - Frontiers in …, 2018 - frontiersin.org
Mycobacteria are well known for their taxonomic diversity, their impact on global health, and
for their atypical cell wall and envelope. In addition to a cytoplasmic membrane and a …

Chemical genetic interaction profiling reveals determinants of intrinsic antibiotic resistance in Mycobacterium tuberculosis

W Xu, MA DeJesus, N Rücker… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Chemotherapy for tuberculosis (TB) is lengthy and could benefit from synergistic adjuvant
therapeutics that enhance current and novel drug regimens. To identify genetic determinants …

The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages

EV Nazarova, CR Montague, L Huang, T La, D Russell… - Elife, 2019 - elifesciences.org
Mycobacterium tuberculosis (Mtb) imports and metabolizes fatty acids to maintain infection
within human macrophages. Although this is a well-established paradigm, the bacterial …

[图书][B] Biology and biotechnology of actinobacteria

J Wink, F Mohammadipanah, J Hamedi - 2017 - Springer
Actinobacteria are Gram positive organisms characterized by normally having a high mol%
G+ C ratio, filamentous or non-filamentous morphologies, and some members that produce …

Cell walls and membranes of Actinobacteria

KC Rahlwes, IL Sparks, YS Morita - Bacterial Cell Walls and Membranes, 2019 - Springer
Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …

Biomarkers for tuberculosis: the case for lipoarabinomannan

M Correia-Neves, G Fröberg, L Korshun… - ERJ open …, 2019 - Eur Respiratory Soc
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent
reports from the World Health Organization. Available tests for TB diagnosis present severe …