Genetic factors of non-obstructive azoospermia: consequences on patients' and offspring health
Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and
is characterized by clinical heterogeneity implying the involvement of several different …
is characterized by clinical heterogeneity implying the involvement of several different …
Genetic intersection of male infertility and cancer
Recent epidemiological studies have identified an association between male factor infertility
and increased cancer risk, however, the underlying etiology for the shared risk has not been …
and increased cancer risk, however, the underlying etiology for the shared risk has not been …
Germline sequencing analysis to inform clinical gene panel testing for aggressive prostate cancer
Importance Germline gene panel testing is recommended for men with advanced prostate
cancer (PCa) or a family history of cancer. While evidence is limited for some genes …
cancer (PCa) or a family history of cancer. While evidence is limited for some genes …
Germline sequencing DNA repair genes in 5545 men with aggressive and nonaggressive prostate cancer
Background There is an urgent need to identify factors specifically associated with
aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely …
aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely …
[HTML][HTML] Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT.
FC Hamdy, JL Donovan, JA Lane… - Health Technology …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Prostate cancer is the most common cancer among men in the UK. Prostate-
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …
DNA damage response in prostate cancer
MJ Schiewer, KE Knudsen - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Prostatic adenocarcinoma (PCa) remains a significant health concern. Although localized
PCa can be effectively treated, disseminated disease remains uniformly fatal. PCa is reliant …
PCa can be effectively treated, disseminated disease remains uniformly fatal. PCa is reliant …
A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer
Purpose Primary breast and prostate cancers can be cured, but metastatic disease cannot.
Identifying cell factors that predict metastatic potential could guide both prognosis and …
Identifying cell factors that predict metastatic potential could guide both prognosis and …
[HTML][HTML] Next generation mapping reveals novel large genomic rearrangements in prostate cancer
Complex genomic rearrangements are common molecular events driving prostate
carcinogenesis. Clinical significance, however, has yet to be fully elucidated. Detecting the …
carcinogenesis. Clinical significance, however, has yet to be fully elucidated. Detecting the …
Patient-level DNA damage repair pathway profiles and anti-tumor immunity for gastric cancer
S Lou, Y Wang, J Zhang, X Yin, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
DNA damage repair (DDR) comprises the detection and correction of alterations in the
chemical structure of DNA. The dysfunction of the DDR process has been determined to …
chemical structure of DNA. The dysfunction of the DDR process has been determined to …
Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry
Background Vitamin D deficiency is more common among African-ancestry individuals and
may be associated with adverse health outcomes. Vitamin D binding protein (VDBP) …
may be associated with adverse health outcomes. Vitamin D binding protein (VDBP) …