Fatty pancreas and cardiometabolic risk: response of ectopic fat to lifestyle and surgical interventions
KH Leiu, SD Poppitt, JL Miles-Chan, IR Sequeira - Nutrients, 2022 - mdpi.com
Ectopic fat accumulation in non-adipose organs, such as the pancreas and liver, is
associated with an increased risk of cardiometabolic disease. While clinical trials have …
associated with an increased risk of cardiometabolic disease. While clinical trials have …
Visceral adiposity index as a predictor of type 2 diabetes mellitus risk: A systematic review and dose–response meta-analysis
F Shen, C Guo, D Zhang, Y Liu, P Zhang - Nutrition, Metabolism and …, 2024 - Elsevier
Aims Considering the positive association between visceral adiposity index (VAI) and type 2
diabetes mellitus (T2DM), no comprehensive assessment on the summarized and dose …
diabetes mellitus (T2DM), no comprehensive assessment on the summarized and dose …
Pancreas fat, an early marker of metabolic risk? A magnetic resonance study of Chinese and Caucasian women: TOFI_Asia study
IR Sequeira, WC Yip, LWW Lu, Y Jiang… - Frontiers in …, 2022 - frontiersin.org
Objective Prevalence of type 2 diabetes (T2D) is disproportionately higher in younger
outwardly lean Asian Chinese compared to matched Caucasians. Susceptibility to T2D is …
outwardly lean Asian Chinese compared to matched Caucasians. Susceptibility to T2D is …
Untargeted metabolomics reveals plasma metabolites predictive of ectopic fat in pancreas and liver as assessed by magnetic resonance imaging: the TOFI_Asia study
Background Excess visceral obesity and ectopic organ fat is associated with increased risk
of cardiometabolic disease. However, circulating markers for early detection of ectopic fat …
of cardiometabolic disease. However, circulating markers for early detection of ectopic fat …
Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes
IR Sequeira, JST Woodhead, A Chan… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Mitochondrial-derived peptides (MDPs) are encoded by the mitochondrial genome and
hypothesised to form part of a retrograde signalling network that modulates adaptive …
hypothesised to form part of a retrograde signalling network that modulates adaptive …
Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study
Abstract Background Asian Chinese are more susceptible to deposition of visceral adipose
tissue (VAT) and type 2 diabetes (T2D) development than European Caucasians when …
tissue (VAT) and type 2 diabetes (T2D) development than European Caucasians when …
Glycaemic Response to a Nut-Enriched Diet in Asian Chinese Adults with Normal or High Glycaemia: The Tū Ora RCT
Nut-based products are a good source of high-quality plant protein in addition to mono-and
polyunsaturated fatty acids, and may aid low-glycaemic dietary strategies important for the …
polyunsaturated fatty acids, and may aid low-glycaemic dietary strategies important for the …
Utilising A Clinical Metabolomics LC-MS Study to Determine the Integrity of Biological Samples for Statistical Modelling after Long Term− 80° C Storage: A TOFI_Asia …
A Joblin-Mills, ZE Wu, IR Sequeira-Bisson… - Metabolites, 2024 - mdpi.com
Biological samples of lipids and metabolites degrade after extensive years in− 80 C storage.
We aimed to determine if associated multivariate models are also impacted. Prior TOFI_Asia …
We aimed to determine if associated multivariate models are also impacted. Prior TOFI_Asia …
A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian …
Nut-based products may aid low-glycaemic dietary strategies that are important for diabetes
prevention in populations at increased risk of dysglycaemia, such as Asian Chinese. This …
prevention in populations at increased risk of dysglycaemia, such as Asian Chinese. This …
Circulatory miRNAs as Correlates of Elevated Intra-Pancreatic Fat Deposition in a Mixed Ethnic Female Cohort: The TOFI_Asia Study
Ectopic lipid accumulation, including intra-pancreatic fat deposition (IPFD), exacerbates type
2 diabetes risk in susceptible individuals. Dysregulated circulating microRNAs (miRNAs) …
2 diabetes risk in susceptible individuals. Dysregulated circulating microRNAs (miRNAs) …