Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Platycodon grandiflorum (Jacq.) A. DC.: A review of phytochemistry, pharmacology, toxicology and traditional use

S Zhang, X Chai, G Hou, F Zhao, Q Meng - Phytomedicine, 2022 - Elsevier
Abstract Background The traditional Chinese medicine Platycodon grandiflorum (Jacq.) A.
DC.(PG, balloon flower) has medicinal and culinary value. It consists of a variety of chemical …

[HTML][HTML] Platycodon grandiflorum root extract inhibits Aβ deposition by breaking the vicious circle linking oxidative stress and neuroinflammation in Alzheimer's …

Y Nam, YJ Ji, SJ Shin, HH Park, SH Yeon… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease accompanied by
irreversible cognitive impairment. A deleterious feedback loop between oxidative stress and …

A prospective review of the health-promoting potential of Jing Si Herbal Tea

TJ Ho, T Ahmed, MA Shibu, YJ Lin, CY Shih… - Tzu Chi Medical …, 2024 - journals.lww.com
Traditional Chinese medicine (TCM) has gained considerable attention over the past few
years for its multicomponent, multitarget, and multi-pathway approach to treating different …

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

YJ Ji, S Kim, JJ Kim, GY Jang, M Moon, HD Kim - Antioxidants, 2021 - mdpi.com
Although Platycodon grandiflorum saponins exhibit many beneficial biological effects in
various diseases and conditions, how they protect nerve cells against neurodegenerative …

Balloon Flower Root-Derived Extracellular Vesicles: In Vitro Assessment of Anti-Inflammatory, Proliferative, and Antioxidant Effects for Chronic Wound Healing

M Kim, H Jang, JH Park - Antioxidants, 2023 - mdpi.com
Excessive reactive oxygen species (ROS) in wound lesions can lead to oxidative stress and
failure of normal wound healing processes, eventually resulting in chronic skin wounds. A …

Antioxidants of natural products

MR Kim - Antioxidants, 2021 - mdpi.com
Antioxidant ingredients are known to contribute to the beneficial effects of natural products in
health promotion as well as disease prevention by reducing oxidative stress, caused by …

[HTML][HTML] Ethnopharmacology, phytochemistry, pharmacology, and product application of Platycodon grandiflorum: A review

L Zhang, X Wang, J Zhang, D Liu, G Bai - Chinese Herbal Medicines, 2024 - Elsevier
Abstract Platycodonis radix (Jiegeng in Chinese) is a well-known traditional Chinese
medicine used for both medicinal and culinary purposes. Its historical use as an antitussive …

Platycodon grandiflorum exhibits anti-neuroinflammatory potential against beta-amyloid-induced toxicity in microglia cells

YJ Ji, MH Kang, GS Kim, HD Kim, GY Jang - Frontiers in Nutrition, 2024 - frontiersin.org
Background/objectives Platycodon grandiflorum (PG) is used in traditional oriental medicine
to treat several ailments. Methods The study investigated the anti-inflammatory and …

The role of plant-based products in the prevention of neurological complications

C Vellapandian - Drug Metabolism and Bioanalysis Letters …, 2022 - benthamdirect.com
Background: Neurological complications are most likely to be fatal and cause loss of ability
to function or care for self. These include Alzheimer's disease and cognitive impairment. The …