Classical biogenic amines (adrenaline, noradrenaline, dopamine, serotonin and histamine)
interact with specific families of G protein‐coupled receptors (GPCRs). The term 'trace …

Recent years have seen an explosion of interest in evidence for positive Darwinian selection
at the molecular level. This quest has been hampered by the use of statistical methods that …

Recent advances in sequencing technology make it possible to comprehensively catalog
genetic variation in population samples, creating a foundation for understanding human …

Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-
borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to …

Background Recent developments in deep (next-generation) sequencing technologies are
significantly impacting medical research. The global analysis of protein coding regions in …

Alternatively spliced brain-derived neurotrophic factor (BDNF) transcripts are targeted to
distinct cellular compartments in neurons but the mechanisms underlying this sorting are …

Background Genotypes generated in next generation sequencing studies contain errors
which can significantly impact the power to detect signals in common and rare variant …

Enrichment capture methods for NGS are widely used, however, they evolve rapidly and it is
necessary to periodically measure their strengths and weaknesses before transfer to …

Next-generation sequencing technologies have made it possible to sequence targeted
regions of the human genome in hundreds of individuals. Deep sequencing represents a …

Abstract The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range
of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is …