Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all
mammalian cells and usually covalently attached to proteins, forming proteoglycans. They …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Abstract Background Cancer Stem Cells (CSCs) have emerged as a critical mediator in
recurrence and resistance in cancers. Kindlin-isoform (1 and 2) binds with cytoplasmic β-tail …

Introduction: Anticoagulants are the mainstay for prevention and/or treatment of thrombotic
disorders. Each clinically used anticoagulant is associated with significant adverse …

The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that
plays critical roles in cancer. Microarray, computational, thermodynamic, and cellular …

Glycosaminoglycans (GAGs) are linear sulfated polysaccharides that exist in most
mammalian cells. By undergoing conjugation with various proteins, GAGs play important …

Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the
treatment of cancers. Cell surface proteoglycans bearing sulfated glycosaminoglycan (GAG) …

Abstract Background Cancer stem cells (CSCs), a subpopulation in tumors, are known to
cause drug resistance, tumor recurrence and metastasis. Based on the characteristic …

Abstract Background Human factor XIa (FXIa) is an actively pursued target for development
of safer anticoagulants. Our long‐standing hypothesis has been that allosterism originating …